BRN 3915507
Sanguinarine
CAS: 2447-54-3
Molecular Formula: C20H14NO4
BRN 3915507 - Names and Identifiers
| Name | Sanguinarine |
| Synonyms | BRN 3915507 Sanguinarin Sanguinarine UNII-AV9VK043SS Pseudochelerythrine Dimethylenedioxy benzphenanthridine 13-methyl[1,3]benzodioxolo[5,6-c][1,3]dioxolo[4,5-i]phenanthridin-13-ium (1,3)-Benzodioxolo(5,6-c)-1,3-dioxolo(4,5-i)phenanthridinium, 13-methyl- |
| CAS | 2447-54-3 |
| EINECS | 219-503-3 |
| InChI | InChI=1/C20H14NO4/c1-21-8-15-12(4-5-16-20(15)25-10-22-16)13-3-2-11-6-17-18(24-9-23-17)7-14(11)19(13)21/h2-8H,9-10H2,1H3/q+1 |
BRN 3915507 - Physico-chemical Properties
| Molecular Formula | C20H14NO4 |
| Molar Mass | 332.335 |
| Melting Point | 205-215ºC |
| Boling Point | 483.53°C (rough estimate) |
| Solubility | Soluble in methanol and ethanol solution, insoluble in petroleum ether and chloroform. |
| Appearance | Pale yellow needle crystal |
| Storage Condition | 2-8 ℃, dark |
| MDL | MFCD00064925 |
| Physical and Chemical Properties | Red needle-like crystals, soluble in organic solvents such as methanol, ethanol, DMSO, etc., are derived from Borneo. |
| Use | A natural product with antibacterial, anti-inflammatory and antioxidant properties. It can inhibit the expansion of tumor cell lines and promote apoptosis. |
BRN 3915507 - Reference
| Reference Show more | 1. Liang Hao, Du Xiaojing, Yu Jiansheng, et al.. Study on Extraction Process of Alkaloids from Boroptera oblaensis by Internal Boiling Method [J]. Heilongjiang Animal Husbandry and Veterinary Medicine (Second Half of Half) 2019 000(007):140-142. 2. Zheng Meixia, Su Hailan, Zhu Yujing. Optimization of Extraction Process of Alkaloids from Boroptera oblaensis [J]. Journal of Food Safety and Quality Inspection 2020 011(010):3087-3091. 3, yu Peili, Jin Yang, et al. Effects of sanguinarine on biomechanical properties of rat airway smooth muscle cells [J]. Journal of Biomedical Engineering, 2018, v.35(04):89-97. 4. Sun Lei, Li Zhao, Wu Huaixiu, et al. Preparation of Recombinant Human Acetylcholinesterase Expression in Vitro and Screening of Related Small Molecule Activities [J]. Journal of Pharmaceutical Analysis, 2019(3):386-392. 5. Zhao Lu, Jiang Jianmei, Meng Qi, et al. Variation of alkaloid content in celandine during growth period [J]. Journal of Jilin Agricultural University, 2017(5):590-595. 6. Jia Changqing, Ma Rui, Wang Dandan, Qian Xicheng, Yu Jiansheng. Separation and Purification of Sanguinarine Hydrochloride and Chelyudine Hydrochloride by Recrystallization [J]. Yunnan Chemical Industry, 2021,48(01):38-41. 7. Liang Hao, Qian Xicheng, Du Xiaojing, Yu Jiansheng. Study on Enhanced Extraction of Sanguinarine by Internal Boiling [J]. Feed Research, 2020,43(09):86-89. 8. Liang Hao, Qian Xicheng, Du Xiaojing, Yu Jiansheng. Optimization of Preparation Process of Sanguinarine β-Cyclodextrin Inclusion Compound by Response Surface Methodology [J]. Tianjin Agricultural Sciences, 2021,27(02):1-5. 9. Luo M, Yu P, Ni K, et al. Sanguinarine Rapidly Relaxes Rat Airway Smooth Muscle Cells Dependent on TAS2R Signaling. Biological & Pharmaceutical Bulletin. 2020 Jul;43(7):1027-1034. DOI: 10.1248/bpb.b19-00825. 10. [IF = 5.546] Fuzhan Zhang et al."anti-osteoporosis activity of Sanguinarine in preosteoblast MC3T3 ‐E1 cells and an ovariectomized rat model." J Cell Physiol. 2018 Jun;233(6):4626-4633 11. [IF = 3.963] Zhong-min Zhao et al."Anti-phytopathogenic activity and the possible mechanisms of action of isoquinoline alkaloid sanguinarine." Pestic Biochem Phys. 2019 Sep;159:51 12. [IF = 3.935] Qiyan Lin et al."Rapid identification and pharmacokinetic studies of multiple active alkaloids in rat plasma through UPLC-Q-TOF-MS and UPLC-MS/MS after the oral administration of Zanthoxylum nitidum extract." J Pharmaceut Biomed. 2020 Jul;186:113232 13. [IF = 2.233] Mingzhi Luo et al."Sanguinarine Rapidly Relaxes Rat Airway Smooth Muscle Cells Dependent on TAS2R Signaling." Biological & Pharmaceutical Bulletin. 2020 May 13 |
BRN 3915507 - Target
| Target | Value |
| PP2C (Cell-free) |
0.68 μM(Ki) |
Last Update：2024-04-10 22:29:15
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View History
BRN 3915507
C.I.颜料黄176
126263-37-4
苦参醇I
GEFITINIB盐酸盐
生物净水剂
化合物 T32115
颜料红212
1431724-30-9
Benzylmercaptoacetic acid
C.I.颜料黄176
126263-37-4
苦参醇I
GEFITINIB盐酸盐
生物净水剂
化合物 T32115
颜料红212
1431724-30-9
Benzylmercaptoacetic acid